Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring.

ABSTRACT:

Importance

Maternal depressive symptoms during the perinatal period have been associated with offspring neurodevelopment. However, the longitudinal association of prenatal and postnatal maternal depressive symptoms with the developmental change in functional brain networks among offspring remains unclear.

Objective

To examine the associations of prenatal and postnatal maternal depressive symptoms with offspring functional brain connectivity development from midchildhood to adolescence.

Design, setting, and participants

This single-site, population-based prospective cohort was embedded in the Generation R Study, conducted in Rotterdam, the Netherlands. All pregnant individuals with an expected delivery date between April 1, 2002, and January 31, 2006, were invited to p

SUBMITTER: Koc D 

PROVIDER: S-EPMC12314728 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature