Anti-angiogenic effects of <i>Moringa oleifera</i> silver nanoparticles on endothelial cells: in vitro and ex vivo studies.

ABSTRACT:

Aim

Angiogenesis, invasion, and tube formation are critical processes in tumor progression and metastasis. The use of nanoparticles derived from natural products presents a promising approach for targeted cancer therapy. This study evaluates the anti-angiogenic and anti-invasive effects of Moringa oleifera silver nanoparticles (MO-AgNPs) as a therapeutic strategy against these processes.

Methods

The anti-angiogenic and anti-invasive activities of MO-AgNPs were investigated using a series of in vitro and ex vivo models. These included the rat aortic ring assay, endothelial tube formation assay, cell invasion assay using endothelial cell lines (Ea.hy926), and a three-dimensional (3D) co-culture spheroid model to simulate tumor microenvironment behavior. Comparisons were

SUBMITTER: Al-Shalabi R 

PROVIDER: S-EPMC12314757 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature