Efficacy of subanaesthetic esketamine on the prevention of postoperative delirium in older adult patients after cardiovascular surgery: protocol for a single-centre, randomised, double-blind, placebo-controlled trial (SEPDOC trial) in China.

ABSTRACT:

Introduction

Postoperative delirium (POD) is a common and serious complication in older adult patients undergoing cardiovascular surgery. Esketamine is known for its anti-inflammatory and neuroprotective properties. While it has shown preventive effects on POD in those not undergoing cardiovascular surgery, its efficacy in older adult patients undergoing cardiovascular surgery remains uncertain. Therefore, we herein aimed to evaluate the preventive effect of intraoperative subanaesthetic esketamine on POD in this specific population.

Methods and analysis

This single-centre, randomised, double-blind, placebo-controlled trial will enrol 778 patients aged 60-80 years undergoing open-heart cardiovascular surgery in China, from September 2023 to December 2025. The participants wi

SUBMITTER: Yan JM 

PROVIDER: S-EPMC12314811 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature