Impact of oral immunotherapy on diversity of gut microbiota in food-allergic children.

ABSTRACT:

Background

Food allergies (FAs) are an increasing public health concern, particularly in children. Oral immunotherapy (OIT) is an emerging treatment strategy under clinical investigation for desensitization of children with FA to food allergens. Dysbiosis of the gut microbiota has been implicated in FAs, and various factors influence its composition; however, the impact of OIT on the gut microbiota remains largely unexplored.

Objective

This study aimed to identify the changes in diversity of the gut microbiota following OIT in children with FA.

Methods

Thirty children with FA (mean age 3.93 years, age range 2.00-14.00) undergoing oral immunotherapy targeting legumes (lentils, peanuts, peas), tree nuts (cashews, hazelnuts, pistachios), animal products (milk, egg), and

SUBMITTER: Bouabid T 

PROVIDER: S-EPMC12314854 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature