Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.

ABSTRACT:

Background

Human milk oligosaccharides (HMOs) are complex carbohydrates that act as prebiotics, supporting infants' gut microbial colonization and immune development. HMO levels are influenced by several maternal factors, including genetics, diet, and health status. In this study, we aim to investigate the effects of ω-3 PUFA (polyunsaturated fatty acids) and Limosilactobacillus (L.) reuteri supplementation on HMO levels in colostrum and mature milk. Another aim is to compare HMO levels between allergic and non-allergic mothers and to explore the correlation between HMOs and secretory immunoglobulin A (SIgA) in milk.

Methods

Milk samples (n = 136) were collected from mothers enrolled in a clinical trial (PROOM-3) designed to investigate the effect of pre- and postnatal suppl

SUBMITTER: Al-Kaabawi A 

PROVIDER: S-EPMC12314855 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature