Soft, Deformable Polyurethane-Boronic Acid Nanoparticles as Dynamic Cross-Linkers to Construct 3D-Bioprintable Hydrogels.

ABSTRACT: Addition of nanoparticles in a hydrogel can enhance its three-dimensional (3D) printability. However, the role of soft, deformable nanoparticles in the 3D printability of a hydrogel network has not been explored so far. In this study, two boronic acid-functionalized polyurethane (PU) nanoparticles PUB and PUB' are synthesized as soft dynamic nanocross-linkers to construct a 3D bioprintable hydrogel. The soft segment of PUB consists of poly(ε-caprolactone) (PCL) solely while that of PUB' consists of PCL, poly(d,l-lactide), and poly(3-hydroxybutyrate) in a 0.7/0.2/0.1 molar ratio. Small-angle X-ray scattering (SAXS) reveals that PUB nanoparticles are nearly spherical while PUB' nanoparticles are ellipsoidal. A PUB'-cross-linked poly(ethylene glycol) hydrogel based on dynamic click chemistry

SUBMITTER: Chang YC 

PROVIDER: S-EPMC12314868 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature