Protocol of the exploratory prospective observational PEAK study: PrEcision medicine in the management of cardiovascular surgery associated Acute Kidney Injury (AKI).

ABSTRACT:

Introduction

Acute kidney injury (AKI) due to temporary renal ischaemia is a common, life-threatening complication of many invasive surgical procedures, particularly among the critically ill, frail and elderly. Since no targeted interventions are currently available, innovative strategies for prediction, early detection and personalised treatment of AKI are urgently needed. Based on our results from preclinical renal ischaemia-reperfusion injury models, we postulate that the excess release of cytotoxic calcium phosphate-loaded particles from dying cells and their reuptake by neighbouring cells drive a self-perpetuating necroinflammatory process causing AKI. Furthermore, replenishing the hepatokine fetuin-A, which is rapidly consumed in this process by binding and rendering inert th

SUBMITTER: Hammer N 

PROVIDER: S-EPMC12315053 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature