Comparative renal effects of angiotensin receptor neprilysin inhibitors and ACEi/ARB: a systematic review and meta-analysis.

ABSTRACT:

Background

Classical renin-angiotensin system inhibitors (RASI), such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB), have long been the foundation of treatment for patients with cardiovascular disease (CVD) and chronic kidney disease (CKD). The development of angiotensin receptor neprilysin inhibitors (ARNI) has introduced a valuable therapeutic option for patients with heart failure with reduced ejection fraction (HFrEF), reducing the risk of major cardiovascular events and becoming an essential component of treatment for this population. However, their effects on renal outcomes remain uncertain.

Methods

We conducted a systematic review and meta-analysis to compare the renal effects of ARNI and RASI. Relevant studies were searche

SUBMITTER: Covic A 

PROVIDER: S-EPMC12315105 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature