The impact of preoperative biliary drainage on bile colonization of patients undergoing pancreaticoduodenectomy.

ABSTRACT:

Background

Preoperative biliary drainage (PBD) may be performed for jaundiced patients with periampullary tumors. This study aimed to evaluate the impact of PBD on biliary microbiome and perioperative complications in patients undergoing pancreaticoduodenectomy (PD).

Methods

This retrospective study enrolled 323 patients who underwent PD between March 2018 and March 2024. Intraoperative bile specimens were obtained for microbiological analysis of species identification and antimicrobial resistance patterns..

Results

PBD was performed in 191 (59.1%) of the 323 patients. Organ/space surgical site infection (SSI) (51.8% vs 37.9%, p < 0.001) and bacterial colonization of bile (90.6% vs 28.0%, p < 0.001) were significantly more frequent in patients with PBD.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12315152 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature