Azelaic acid attenuates CCL2/CCR2 axis-mediated skin trafficking of acute myeloid leukemia cells through NF-κB/MAPK signaling modulation in keratinocytes.

ABSTRACT:

Background

The involvement of CCL2/CCR2 in leukemic cell infiltration into the skin, specifically in leukemia cutis (LC), remains largely unexplored. Oxidative stress has been demonstrated to induce the upregulation of CCL2 expression, while the antioxidant properties of azelaic acid (AZA) have been proven to exert anti-acute myeloid leukemia (AML) effects.

Aims

To investigate the role of CCL2/CCR2 in the pathogenesis of leukemia cutis, and to evaluate whether azelaic acid (AZA) can inhibit the infiltration of leukemic cells into the skin and its possible mechanism.

Methods

The migratory capacity of leukemic cells toward skin tissue was evaluated in vitro to determine the effects of CCL2/CCR2 and its modulation by AZA treatment. Concurrently, the regulatory effects of

SUBMITTER: Jiang S 

PROVIDER: S-EPMC12315206 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature