Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus.

ABSTRACT: Male genital lichen sclerosus (LS), a chronic inflammatory dermatological condition, has been recognized for its profound implications on the quality of life among males. The exact etiological factors behind this prevalent condition remained largely enigmatic. In this research, we employed a multi-omics strategy to identify and elucidate the underlying histological biomarkers and the fundamental pathogenesis associated with male genital LS. A comprehensive cell atlas of male genital LS disease was constructed, highlighting a pronounced increase in T cells and a remarkable reduction in keratinocytes within the male genital LS samples. Further insights elucidated the enhanced crosstalk between fibroblasts and T cells via the collagen-CD44 axis, and between fibroblasts and keratinocytes throu

SUBMITTER: Lin L 

PROVIDER: S-EPMC12315299 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature