Extrahepatic disease clusters and mortality in people with steatotic liver diseases: a prospective analysis of 64,749 females and 113,587 males in the UK Biobank.

ABSTRACT:

Background

Steatotic liver disease (SLD) is the most prevalent chronic liver disease worldwide and linked to various liver and extrahepatic diseases. However, the clustering of extrahepatic conditions and their impact on mortality in individuals with SLD remain poorly understood.

Methods

We used UK Biobank data to identify sex-specific disease clusters among individuals with SLD and multimorbidity (having ≥ 2 extrahepatic diseases) using latent class analysis. Multivariable Cox models were used to assess associations between multimorbidity, disease clusters and all-cause mortality and mortality from cardiovascular diseases (CVD), extrahepatic cancers, liver-related diseases and hepatocellular carcinoma.

Results

Among 178,336 (36.3% female) individuals with SLD, during

SUBMITTER: Feng Q 

PROVIDER: S-EPMC12315339 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature