Mechanisms of cell senescence and apoptosis in cyclophosphamide-induced premature ovarian failure in rats.

ABSTRACT:

Background

Premature ovarian failure (POF) is a clinical condition characterized by a diminished ovarian reserve occurring before the age of 40, significantly affecting female reproductive health. However, its exact pathogenesis remains unclear. This research aimed to examine the mechanisms of cyclophosphamide (CTX)-induced senescence and apoptosis in the ovarian and cerebral cortex tissues of rats to provide insights into delaying aging and protecting female reproductive health.

Methods

A rat model of POF was established by intraperitoneal injection of CTX. Model efficacy was evaluated by measuring ovarian volume, weight, estrogen, and anti-Müllerian hormone levels. Serum marker changes were detected via enzyme-linked immunosorbent assay (ELISA). Senescence and apoptosis in

SUBMITTER: Wu J 

PROVIDER: S-EPMC12315350 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature