Obstetric complications, cortical gyrification, and cognition in first-episode psychosis.

ABSTRACT:

Background

Obstetric complications (OCs) are associated with cognitive and brain abnormalities observed in patients with schizophrenia. Gyrification, a measure of cortical integrity sensitive to events occurring during the prenatal and perinatal periods, is also altered in first-episode psychosis (FEP). We examined the relationship between OCs and gyrification in FEP, as well as whether gyrification mediates the relationship between OCs and cognition.

Methods

We examined differences in the Local Gyrification Index (LGI) for the frontal, parietal, temporal, occipital, and cingulate cortices between 139 FEP patients and 125 healthy controls (HCs). Regression analyses explored whether OCs and diagnosis interact to explain LGI variation. Parametric mediation analyses were conduc

SUBMITTER: Costas-Carrera A 

PROVIDER: S-EPMC12315652 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature