Characterizing intraindividual variability in bipolar disorder: links to cognition, white matter microstructure, and clinical variables.

ABSTRACT:

Background

Most cognitive studies of bipolar disorder (BD) have examined case-control differences on cognitive tests using measures of central tendency, which do not consider intraindividual variability (IIV); a distinct cognitive construct that reliably indexes meaningful cognitive differences between individuals. In this study, we sought to characterize IIV in BD by examining whether it differs from healthy controls (HCs) and is associated with other cognitive measures, clinical variables, and white matter microstructure.

Methods

Two hundred and seventeen adults, including 100 BD outpatients and 117 HCs, completed processing speed, sustained attention, working memory, and executive function tasks. A subsample of 55 BD participants underwent diffusion tensor imaging. IIV wa

SUBMITTER: Caruana GF 

PROVIDER: S-EPMC12315665 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature