Sensitivity of unconstrained quantitative magnetization transfer MRI to amyloid burden in preclinical Alzheimer's disease.

ABSTRACT: Magnetization transfer MRI is sensitive to semisolid macromolecules, includingamyloid beta, and has previously been used to discriminate Alzheimer'sdisease (AD) patients from controls. Here, we fit an unconstrained 2-poolquantitative MT (qMT) model, that is, without constraints on the longitudinalrelaxation rate R1s of semisolids, and investigate the sensitivity of the estimated parameters toamyloid accumulation in preclinical participants. We scanned 15 cognitivelynormal volunteers, of which 9 were amyloid positive by[¹⁸F]florbetaben PET. A 12 min hybrid-state qMT scan with aneffective resolution of 1.24 mm isotropic and whole-brain coverage was acquiredto estimate the unconstrained 2-pool qMT parameters. Group comparisons andcorrelations with florbetaben PET standardized uptak

SUBMITTER: Mao A 

PROVIDER: S-EPMC12315764 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature