Unraveling α-synuclein and amylin co-aggregation: pathological insights and biomarker development for Parkinson's disease.

ABSTRACT: Background: Patients with diabetes have a higher morbidity in Parkinson's disease (PD) than others, but the mechanism underlying this link remains controversial. The co-aggregation of α-synuclein (α-syn) and amylin has been hypothesized as a key contributor. Methods: Molecular interaction analysis and co-immunoprecipitation were conducted to assess the feasibility of co-aggregation. We developed a tailored surface-based fluorescence distribution method to detect the co-aggregate in the subject's serum sample and brain-derived L1CAM-positive Extracellular Vesicles. Subjects include Health Controls (HC), PD patients and multiple system atrophy (MSA) patients. Results: The co-aggregates were detected in PD patient samples, in both serum and brain-derived extracellular ves

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12315819 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature