P75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia.

ABSTRACT: Children who have experienced moderate perinatal hypoxia are at risk of developing long-lasting subtle cognitive and behavioural deficits, including learning disabilities and emotional problems. Understanding the underlying mechanisms is an essential step for designing targeted therapy. Fast-spiking, parvalbumin (PV)-positive GABAergic interneurons modulate the generation of gamma oscillations, which, in turn, regulate many cognitive functions, including goal-directed attentional processing and cognitive flexibility. Owing to their fast firing rate, PV cell function requires high levels of energy, which might render them highly vulnerable to conditions of metabolic and oxidative stress caused by perinatal hypoxia. Here, we show that adult mice that experienced moderate perinatal hypoxia ha

SUBMITTER: Chattopadhyaya B 

PROVIDER: S-EPMC12316007 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature