Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration.

ABSTRACT: As the world's population ages, more and more people are expected to suffer from age-related diseases. Biological ageing markers derived from DNA methylation and brain structure show promise in predicting health outcomes. Understanding the relationship between these biomarkers can promote the development of effective health interventions. In a sample of 254 participants from the Netherlands Twin Register (20-84 years), we investigated associations between DNA methylation age acceleration based on five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge and DunedinPACE) and brain age acceleration based on neuroimaging (brainageR). Furthermore, we applied bivariate twin models to examine the contribution of genetic and environmental factors to the associations (cross-twin cross-trait c

SUBMITTER: Sant'Anna Barbosa Ferreira P 

PROVIDER: S-EPMC12316020 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature