Tumor Exosomal HIF2A Induce Peritumoral M2 Macrophages Accumulation to Facilitate Intestinal Invasion in Colorectal Cancer.

ABSTRACT: Background: Local intestinal invasion of tumor cells often leads to recurrent and refractory colorectal cancer (CRC). However, the driven mechanism is not fully understood. Methods: A total of 145 patients with CRC and 10 patients with intestinal perforations or benign lesions were randomly enrolled. The distribution and clinical relevance of macrophages in different tissues were determined by flow cytometry and immunohistochemistry. PCR screening and RNA-sequencing analysis were used to explore the regulatory mechanisms. The functions of macrophages were further verified using an orthotopic mouse model of Csf1r^creCxcr4^fl/fl mice. Results: Here, we unveil the role of M2 macrophages in local intestinal invasion. M2 macrophages infiltrated mo

SUBMITTER: Wang D 

PROVIDER: S-EPMC12316027 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature