Metabolic Targeting of Oxidative Phosphorylation Enhances Chemosensitivity in Triple-Negative Breast Cancer via a Synergistic Nanomedicine.

ABSTRACT: Rationale: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer. There are very few targeted treatment options with satisfactory therapeutic indexes for TNBC. Although chemotherapy is the principal treatment modality for TNBC, its effectiveness is significantly compromised by low chemosensitivity in the TNBC patient population. Recent evidence has suggested that metabolic adaptation of tumor cells may play a critical role in reducing therapeutic responses. Metabolic interventions could enhance chemosensitivity and improve chemotherapeutic efficacy. Methods: The influence of oxidative phosphorylation (OXPHOS) on TNBC chemosensitivity was evaluated by integrating bioinformatic analyses of patient datasets with metabolic phenotyping of TNBC cells. The corr

SUBMITTER: Shen X 

PROVIDER: S-EPMC12316031 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature