Tetrahydromagnolol induces autophagic cell death by targeting the m⁶A reader protein YTHDF2 and enhances the efficacy of anti-PD-1 immunotherapy in pancreatic cancer cells.

ABSTRACT: Rationale: Tetrahydromagnolol (THM) is a bioactive compound derived from Magnolia officinalis. Although other compounds from this plant, such as magnolol and honokiol, have shown significant anticancer potential, the anticancer activities of THM remain unreported. This study aims to investigate the anticancer effects and underlying molecular mechanisms of THM in pancreatic cancer cells. Methods: In this study, the effects of THM on pancreatic cancer cells were investigated by various experiments both in vitro and in vivo. The molecular target of THM in pancreatic cancer cells was determined by transcriptomics, ligand coupled epoxy-activated magnetic beads, CETSA, SPR analysis, ITC analysis, LC-MS/MS analysis, and MD simulations. Results: Our findin

SUBMITTER: Li G 

PROVIDER: S-EPMC12316034 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature