Engineered RAP-anchored copper-escorting liposomes for FDX1-targeted cuproptosis in glioblastoma therapy‌.

ABSTRACT: Rationale: Glioblastoma multiforme (GBM), the most aggressive primary brain malignancy, presents considerable therapeutic challenges due to intrinsic treatment resistance and dismal clinical outcomes. Capitalizing on emerging insights into cuproptosis-mediated oncotherapy, we have developed a receptor-associated protein (RAP)-modified liposomal nanoplatform (RAP-LPs@ESCu) for the precise delivery of elesclomol-copper complexes (ESCu) and aimed to evaluate its therapeutic potential in triggering tumor-specific cuproptosis. Methods: RAP-LPs@ESCu were synthesized via thin-film hydration and characterized by transmission electron microscope (TEM) and dynamic light scatting. Intracellular copper levels were quantified via atomic absorption spectroscopy. RNA sequencing was used to

SUBMITTER: Liu MM 

PROVIDER: S-EPMC12316038 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature