Feeding intervention potentiates the effect of mechanical loading to induce new bone formation in mice.

ABSTRACT: The benefits of increased human lifespan depend upon duration of healthy, independent living; the healthspan. Bone-wasting disorders contribute significantly to loss of independence, frailty, and morbidity in older people. Therefore, there is an unmet need globally for lifestyle interventions to reduce the likelihood of bone fractures with age. Although many mechanisms are involved in disorders of bone loss, there is no single regulatory pathway and, therefore, there is no single treatment available to prevent their occurrence. Our aim in these studies was to determine whether fasting/feeding interventions alter the effect of mechanical loading on bone anabolic activities and increase bone mass. In young 17-week-old mice, 16-hour fasting period followed by reintroduction of food for 2 hour

SUBMITTER: Samvelyan HJ 

PROVIDER: S-EPMC12316085 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature