X-ray microtomography reveals a lattice-like network within aortic elastic lamellae.

ABSTRACT: The arterial wall consists of three concentric layers: intima, media, and adventitia. Beyond their resident cells, these layers are characterized by an extracellular matrix (ECM), which provides both biochemical and mechanical support. Elastin, the major component of arterial ECM, is present in the medial layer and organized in concentric elastic lamellae that confer resilience to the wall. We explored the arterial wall structures from C57Bl6 (control), db/db (diabetic), and ApoE^-/- (atherogenic) mice aged 3 months using synchrotron X-ray computed microtomography on fixed and unstained tissues with a large image field (8 mm³ ). This approach combined a good resolution (0.83 µm/voxel), large 3D imaging field. and an excellent signal to noise ratio conferred by phase-co

SUBMITTER: Ben Zemzem A 

PROVIDER: S-EPMC12316089 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature