Renal Implications of Kappa Opioid Receptor Signaling in Sprague-Dawley Rats.

ABSTRACT: Opioid use for pain management and illicit consumption has been associated with adverse cardiovascular and cardiorenal outcomes. Despite these associations, the mechanisms underlying opioid-induced kidney damage remain poorly understood. Recently, we demonstrated that stimulation of kappa opioid receptors (KOR) is implicated in the aggravation of salt-sensitive hypertension, glomerular injury, and podocyte damage through excessive podocyte calcium influx. This study aims to elucidate the KOR signaling and renal outcomes underlying opioid use in Sprague-Dawley (SD) rats. Here, we employed freshly isolated glomeruli from SD male rats and immortalized human podocyte cell cultures to investigate the role of KORs in podocyte calcium regulation and overall glomerular function. A glomerular perme

SUBMITTER: Didik S 

PROVIDER: S-EPMC12316101 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature