Clock-dependent regulation of a homeostatic sleep center maintains daytime sleep and evening activity.

ABSTRACT: Homeostatic sleep centers promote sleep in response to prolonged wakefulness, but their contribution to circadian-regulated daily sleep is still unclear. Do neuronal circuits driving rebound sleep after extended wakefulness also drive circadian-gated sleep, or does rebound sleep differ on a neurophysiological level from daily baseline sleep? We observed in Drosophila that 23E10+ neurons, which include a homeostatic sleep center, the dorsal fan-shaped body (dFSB),^1,2,3,4,5 promote sleep in a time-of-day-dependent manner-the neurons play the strongest role in the maintenance of daytime sleep, and this effect on the siesta maps to cholinergic neurons within the dFSB. We asked whether 23E10+ neur

SUBMITTER: Hsu CT 

PROVIDER: S-EPMC12316106 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature