Passive smoking and risk of head and neck cancer: a systematic review and meta-analysis.

ABSTRACT: Studies on the association between passive smoking and head and neck cancer (HNC) are controversial. This meta-analysis aimed to explore this association. A systematic search of the PubMed , Embase , Web of Science , and Cochrane Library databases was conducted up to July 2024 to identify relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the DerSimonian-Laird random-effects model. Heterogeneity among studies was assessed, and the risk of bias was evaluated. A total of 1036 records were identified, of which 17 studies were included. Passive smoking was significantly associated with an increased risk of HNC overall (OR = 1.70, 95% CI: 1.27-2.28, P  < 0.001). The association was particularly strong for oral cancer (OR = 1.85, 95% CI: 1.07-3.1

SUBMITTER: Xu F 

PROVIDER: S-EPMC12316123 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature