Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms.

ABSTRACT: The presence of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) is a hallmark of MOG antibody-associated disease (MOGAD), a recently defined demyelinating disease entity presenting with core clinical features of optic neuritis, myelitis, and acute disseminated encephalomyelitis. Although MOG antibodies have also been described in a small number of patients with other conditions, including mental disorders, their prevalence and clinical specificity in patients with isolated psychotic symptoms remain unclear. Here, we screened sera from 262 patients with at least one psychotic episode and 166 control subjects for the presence of MOG antibodies of the immunoglobulin G (IgG) isotype with a live cell-based assay. Serum reactivity to additional antigens was assessed by immunohis

SUBMITTER: van de Burgt NA 

PROVIDER: S-EPMC12316182 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature