Genotype distribution of human papillomavirus among women with cervical cancer stratified by HIV status in Tanzania.

ABSTRACT:

Background

Cervical cancer (CC) is the leading cancer among women in Tanzania, especially among those between the ages of 15 and 44. The prevalence of high-risk Human papillomavirus (HR-HPV)-16/18 women in the general population at any given time is 3.3%. HR-HPVs 16 or 18 are the primary cause of CC. The distribution of HPV genotypes among women with CC according to HIV status is unknown in Tanzania. This study aimed to determine the HPV genotype distribution according to HIV status among women with CC in Tanzania.

Methods

This cross-sectional study was done at Ocean Road Cancer Institute (ORCI) in Tanzania among women with histologically confirmed CC. HIV serology testing was performed. Biopsy was taken from cervical lesions, and DNA was extracted. HPV DNA was amplified by

SUBMITTER: Mrema A 

PROVIDER: S-EPMC12316304 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature