Arterial cardiovascular outcomes and venous thromboembolism in patients with primary Sjogren's syndrome: a Danish cohort study.

ABSTRACT:

Objective

To evaluate whether atherosclerotic cardiovascular disease outcomes, venous thromboembolism, heart failure, and cardiovascular mortality are elevated in patients with primary Sjögren's syndrome (pSS) compared with a matched cohort from the general population.

Methods

We conducted a nationwide population-based cohort study including all patients with a pSS diagnosis from 1996 to 2017 in Denmark, matched with a comparison cohort on age, gender, and calendar year. The cumulative incidence of each outcome was computed using hospital contact diagnoses as the end point. We used Cox regression to calculate hazard ratios (HRs) for the endpoints, adjusted for potential confounding factors.

Results

The study included 4697 pSS patients (median age 57 years, 87% women)

SUBMITTER: Loiseau P 

PROVIDER: S-EPMC12316372 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature