Trans-omics landscape of systemic vasculitis identified matrix metalloproteinase 12 as a novel signature molecule.

ABSTRACT:

Objectives

To identify key molecules involved in the disease pathophysiology of systemic vasculitis through trans-omics analysis, with a specific focus on demonstrating matrix metalloproteinase (MMP) 12 as a potential biomarker in rheumatic entities.

Methods

Patients with newly diagnosed or relapsed rheumatic and musculoskeletal diseases from June 2013 until September 2022 were enrolled. We screened vasculitis-specific molecules by combining findings from serum proteome analysis and whole-blood RNA sequencing. We further validated the identified molecules using immunohistochemical staining and spatial transcriptome analysis.

Results

Serum proteome and RNA sequencing identified MMP12 as a significant molecule for systemic vasculitis; it distinguished vasculitis from ot

SUBMITTER: Matsumoto K 

PROVIDER: S-EPMC12316376 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature