Real-World Genomic Landscape of Gastrointestinal Cancers in Asia and the Middle East Using Comprehensive Circulating Tumor DNA Next-Generation Sequencing.

ABSTRACT:

Introduction

Gastrointestinal malignancies account for 25% of all cancer cases and 35% of cancer-related mortality. Next-generation sequencing (NGS) can elucidate the genomic landscape of gastrointestinal cancers; tissue-based genotyping has traditionally been used, but liquid biopsy-based genotyping is a non-invasive alternative. Moreover, geographical variations in the genomic landscape of gastrointestinal cancers have not been fully elucidated. This retrospective study aimed to gain insight into the genomic landscape of patients with gastrointestinal cancers from the Asia and Middle East (AME) region using plasma-derived circulating tumor DNA (ctDNA).

Methods

From routine clinical practice, 2,601 plasma samples were collected from 2,062 patients with gastrointestinal canc

SUBMITTER: Muto M 

PROVIDER: S-EPMC12316443 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature