Kounis Syndrome Induced by Atezolizumab in a Patient with Non-Small Cell Lung Cancer: A Case Report.

ABSTRACT:

Introduction

Kounis syndrome (KS) is a rare and often underdiagnosed condition characterized by acute coronary syndromes triggered by allergic or anaphylactic reactions. This syndrome is particularly relevant in the context of immunotherapy, where immune checkpoint inhibitors (ICIs) such as atezolizumab are increasingly used in the treatment of advanced cancers. While atezolizumab is generally well-tolerated, immune-related adverse events, including cardiovascular toxicity, have been reported. Understanding the potential for ICIs to induce severe complications like KS is essential for ensuring patient safety and effective management.

Case presentation

A smoker in their 70s with metastatic lung adenocarcinoma experienced an anaphylactic reaction during the second cycle of ate

SUBMITTER: Agostara AG 

PROVIDER: S-EPMC12316447 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature