PDL1 Expression and Outcomes in Histiocytic Neoplasms.

ABSTRACT:

Introduction

Histiocytic sarcoma (HS) and interdigitating dendritic cell sarcoma (IDCS) are both extremely rare and aggressive histiocytic neoplasms that are most often treated with lymphoma-based chemotherapy; however, there is growing use of immune checkpoint inhibitors (ICI) in the second- or further-line settings as prognosis is typically poor in these neoplasms.

Case presentations

We describe two cases: first, HS in a 60-year-old man with primary tumor in the right anterior lower limb, and second, IDCS in an 82-year-old man in the right para-parotid region after initial wide local excision of a right postauricular mass suggestive of a pleomorphic undifferentiated sarcoma. Systemic imaging showed retroperitoneal, inguinal, and pelvic adenopathy in the first case and no d

SUBMITTER: Moon MJ 

PROVIDER: S-EPMC12316448 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature