Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry.

ABSTRACT: While the exterior of vertebrate bodies appears bilaterally symmetrical, internal organ positioning and morphology frequently exhibit left-right (L-R) asymmetries. In several vertebrates, including human, mouse, frog, and zebrafish, left-right symmetry-breaking during embryonic development is initiated by a ciliated organ called the Node or left-right organizer. Within the Node, a leftward flow of extraembryonic fluid named the Nodal flow mediates the asymmetric expressions of Nodal factors. Although downstream Nodal pathway components leading to the establishment of the embryonic left-right axis are well known, less is known about the development and formation of the embryonic Node itself. Here, we reveal a novel role for the Meteorin protein family in the establishment of the left-right

SUBMITTER: Eggeler F 

PROVIDER: S-EPMC12316458 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature