Soluble PD-L1 as a diagnostic and prognostic biomarker in resectable gastric cancer patients.

ABSTRACT:

Background

In this study, we compared programmed death-ligand 1 (PD-L1) expression in primary tissue samples and its soluble form (sPD-L1) concentration in matched preoperative plasma samples from gastric cancer patients to understand the relationship between tissue and plasma PD-L1 expression and to determine its diagnostic and prognostic value.

Methods

PD-L1 expression in tissue was assessed by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), and sPD-L1 concentration in plasma was quantified by ELISA. The levels of the CD274 gene, which encodes for PD-L1 protein, were examined as part of bulk tissue RNA-sequencing analyses. Additionally, we evaluated the association between sPD-L1 levels and various laboratory parameters, disease characteristics, and pat

SUBMITTER: Chivu-Economescu M 

PROVIDER: S-EPMC12316475 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature