Associations of Stem Cell Markers with Lobular Involution in Benign Breast Tissue.

ABSTRACT:

Background

Terminal duct lobular unit (TDLU) involution has been linked to decreased breast cancer risk in some studies. Whether the number/activity of breast stem cells (SC) in noncancerous tissue may influence TDLU involution is unknown. We examined the associations of CD44, CD24, and aldehyde dehydrogenase family 1 member A1 (ALDH1A1) SC markers with TDLU involution.

Methods

We included 309 cancer-free women with biopsy-confirmed benign breast disease. IHC was performed using tissue microarrays. For each core, IHC expression was assessed using semiautomated software as the percentage of positively stained cells for each marker. Eight TDLU involution measures were assessed with an established computational pathology algorithm. Generalized linear regression was used to exam

SUBMITTER: Yaghjyan L 

PROVIDER: S-EPMC12316557 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature