Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer.

ABSTRACT: Precision medicine and genomic profiling with target-specific therapy directed to cancer cell receptors have improved the outcome of many recalcitrant cancers. Strategies to deliver gene therapy to downregulate cancer driver genes have been challenging in vivo. Pancreatic cancer has the poorest survival of all solid tumors due to the lack of target-specific therapies and its characteristic tumor microenvironment with dense fibrosis and abundant immunosuppressive M2-polarized macrophages. In this study, we designed a panel of locked nucleic acid gapmer antisense oligonucleotides directed to human gastrin mRNA. We tested their efficacy by downregulation of mRNA and growth inhibition in vitro. The most effective gapmer, gapmer-90, was modified for in vivo therapeutics by thiol-maleimide click

SUBMITTER: Smith JP 

PROVIDER: S-EPMC12316562 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature