Physiological and clinical effects of two ultraprotective ventilation strategies in patients with veno-venous extracorporeal membrane oxygenation: the ECMOVENT study.

ABSTRACT:

Purpose

The optimal ventilation strategy in acute respiratory distress syndrome (ARDS) patients with veno-venous extracorporeal membrane oxygenation (VV-ECMO) remains unknown. We aimed to compare the effects of two ultra-protective ventilatory strategies applied to patients with ARDS and VV-ECMO.

Methods

Our study was an observational, retrospective, single-center study with a before-and-after design. All consecutive patients treated with VV-ECMO for severe ARDS between 2016 and 2023 were included. Before 2021, patients received a quasi-apneic ventilation strategy in assist-controlled volume mode with a tidal volume (V_T) of 1 ml.kg^-1 predicted body weight (PBW), a respiratory rate (RR) of 5 min^-1 and a PEEP set to keep plateau pressure (P

SUBMITTER: Rodriguez Y 

PROVIDER: S-EPMC12316621 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature