High risk of drug-resistant tuberculosis in IGRA-negative contacts: should preventive treatment be considered?

ABSTRACT:

Purpose

Deciding whether to provide preventive treatment to contacts of individuals with multidrug-resistant (MDR) tuberculosis is complex.

Methods

We present the diagnostic pathways, clinical course and outcome of tuberculosis treatment in eight siblings from a single family. Tuberculosis disease was diagnosed by Mycobacterium tuberculosis culture and molecular detection of M. tuberculosis-specific DNA from bronchopulmonary specimens using GeneXpert^® MTB/RIF. M. tuberculosis infection was diagnosed by an interferon-gamma release assay (IGRA; QuantiFERON^®-TB Gold Plus). Whole exome sequencing for genetic predisposition to mycobacterial infection was performed in one patient.

Results

Six of eight siblings aged 16-20 years from a migrant family of

SUBMITTER: Brehm TT 

PROVIDER: S-EPMC12316788 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature