External validation of nomograms including PSMA PET information for the prediction of lymph node involvement of prostate cancer.

ABSTRACT:

Background

Novel nomograms predicting lymph node involvement (LNI) of prostate cancer (PCa) including PSMA PET information have been developed. However, their predictive accuracy in external populations is still unclear.

Purpose

To externally validate four LNI nomograms including PSMA PET parameters (three Muehlematter models and the Amsterdam-Brisbane-Sydney model) as well as the Briganti 2012 and MSKCC nomograms.

Methods

Patients with histologically confirmed PCa undergoing preoperative MRI and PSMA PET/CT before radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND) were included. Model discrimination (AUC), calibration and net benefit using decision curve analysis were determined for each nomogram.

Results

A total of 437 patients were

SUBMITTER: Van Bergen TD 

PROVIDER: S-EPMC12316820 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature