Elderly individuals exhibit dysregulated monocyte responses to viral immune complexes compared to adults and children.

ABSTRACT: The severity of certain viral infectious diseases varies across the age; we hypothesize that these variations could be related to the variation of immune responses to viral immune complexes (ICs) among the age. This study aimed to investigate monocyte activation in response to ICs in children, adults, and elderly individuals. An experimental in vitro model was established using peripheral blood mononuclear cells from healthy individuals. Monocyte activation markers (CD169, CD38, HLA-DR), the negative co-stimulatory molecule (PD-L1), and cytokine production were measured under basal conditions and upon stimulation with human adenovirus 5-IgG immune complex (Ad5-ICs), interferon-alpha (IFN-α), and lipopolysaccharide (LPS). Monocytes from children and adults displayed similar activation profi

SUBMITTER: Domitien Payet L 

PROVIDER: S-EPMC12316873 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature