METTL5 regulates SEPHS2-mediated selenoprotein synthesis to promote multiple myeloma survival and progression.

ABSTRACT: The abnormal expression of m⁶A methyltransferase is a significant factor in the occurrence and progression of tumors. The 18S ribosomal RNA (rRNA) m⁶A methyltransferase Methyltransferase-like 5 (METTL5) is upregulated in various cancers, leading to adverse prognosis by abnormally regulating protein translation in tumor cells. However, the functionality and molecular mechanisms of METTL5 in the progression of multiple myeloma (MM) remain unknown. In this study, we demonstrate that the expression of METTL5 in the bone marrow (BM) of newly diagnosed MM patients is significantly higher than in healthy individuals and patients in remission following treatment. Importantly, we found that MM patients with upregulated METTL5 expression had a poorer prognosis. Additionally, we

SUBMITTER: Jiang J 

PROVIDER: S-EPMC12316883 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature