Stellate ganglion irradiation alleviates airway inflammation in asthmatic mice via activating SIRT1 signaling pathway.

ABSTRACT: Asthma is a chronic inflammatory respiratory disease that seriously affects patients' quality of life. Although various pharmacological treatments are currently available, some patients still have poor responses, highlighting the urgent need for new intervention strategies. In recent years, stellate ganglion irradiation (SGI), as an emerging neuromodulation technique, has shown unique therapeutic advantages in various inflammatory diseases. However, the mechanism by which SGI alleviates asthma remains unclear. Silent information regulator 1 (SIRT1), an NAD+-dependent histone deacetylase, plays a key role in regulating cellular inflammatory responses by inhibiting NF-κB and other inflammatory signaling pathways. Given the involvement of SIRT1 and NF-κB imbalance in the pathogenesis of asthm

SUBMITTER: Zhao K 

PROVIDER: S-EPMC12316960 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature