Three-dimensional tooth morphology in patients with tooth agenesis and its association to agenesis pattern, severity, and sex.

ABSTRACT: Non-syndromic tooth agenesis (TA) can affect both the size and shape of teeth and may interact with sex. This study aimed to advance our understanding of tooth developmental mechanisms by constructing a multifactorial model integrating 3D dental morphology, TA patterns, severity, and sex differences. Digital dental models of 255 Japanese individuals (control: 187; TA: 68) were analyzed. We assessed the contributions of size and shape to sex- and TA-related differences in maxillary central incisors (UI) and first molars (UM) using surface distance mapping and a tooth agenesis-associated shape difference (TAShD) analysis. Additionally, permutation tests were conducted to evaluate the relationship between sex- and TA-associated morphological variation. TA patterns were further classified usin

SUBMITTER: Tanikawa C 

PROVIDER: S-EPMC12317028 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature