Curcumin Induces Transgenerational and Sex-Specific Effects on Lifespan, Gene Expression, and Metabolism in the Fruit Fly Drosophila melanogaster.

ABSTRACT: Curcumin is a bioactive compound found in turmeric (Curcuma longa) and is widely recognized for its health-promoting effects, including anti-inflammatory, antioxidant, and anti-carcinogenic properties. It can also mediate epigenetic effects by inhibiting histone acetylases (HATs) and deacetylases (HDACs) but the transgenerational context has not been studied in detail. Here, we used the fruit fly (Drosophila melanogaster) as a model organism to determine the epigenetic effects of 0.1% and 1% (w/v) curcumin, which have been shown to promote the health and prolong the lifespan of fruit flies. Both concentrations were found to significantly increase lifespan and climbing activity in male and female flies, but changes in HAT/HDAC gene expression and metabolism were sex-specific. Unexpectedly,

SUBMITTER: Hof-Michel S 

PROVIDER: S-EPMC12317048 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature