Low Cholinesterase Is a Potential Poor Prognostic Factor in Colorectal Cancer Presenting With Tumor Markers Negative.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common malignant tumor in the world and has the second highest mortality rate. Tumor markers are proteins used to diagnose and monitor cancer. Serum cholinesterase (CHE) is a nutritional indicator indicating the liver''s ability to synthesize proteins and is a predictor of CRC. Butyrylcholinesterase (BCHE), a CHE enzyme encoded by the BCHE gene, is synthesized by the liver and released into the serum.

Objective

To study the association between CHE and survival prognosis in CRC with tumor markers negative (TMN). The relationship between the BCHE gene and immune cell infiltration was also explored.

Methods

The clinical data of patients with CRC were collected. The data included tumor markers and biochemical indicators

SUBMITTER: Alburiahi TAH 

PROVIDER: S-EPMC12317114 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature