Lung structural cells are altered by infeluenza virus leading to rapid immune protection following re-challenge.

ABSTRACT: Lung structural cells form barriers against pathogens and trigger immune responses following infections. This leads to the recruitment of innate and adaptive immune cells some of which remain within the lung and contribute to enhanced pathogen control following subsequent infections. There is growing evidence that structural cells also display long-term changes following infection. Here we investigate long-term changes to mouse lung epithelial cells, fibroblasts, and endothelial cells following influenza virus infection finding that all three cell types maintain an imprint of the infection, particularly in genes linked to communication with T cells. MHCI and MHCII proteins continue to be expressed at higher levels in both differentiated epithelial cells and progenitor populations and sever

SUBMITTER: Worrell JC 

PROVIDER: S-EPMC12317152 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature