Diagnostic and inclusion criteria in Alzheimer's disease clinical trials: A systematic review of the past decade.

ABSTRACT:

Background

Dementia, mainly caused by Alzheimer's disease (AD), is a leading cause of mortality and disability in the elderly. However, inconsistencies in diagnostic and inclusion criteria challenge the design and comparability of AD clinical trials.

Objective

To review recent AD clinical trials, focusing on diagnostic methods and inclusion criteria, and identify trends and gaps to inform future research.

Methods

We systematically searched Web of Science, PubMed, and Google Scholar for AD clinical trials, extracting data on diagnostic criteria, disease stage, cognitive assessments, biomarker use, and participant age.

Results

Of the 27,471 articles screened, 71 studies were included in the final review. Most were conducted in North America (52%) and Europe (34%)

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12317185 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature